Although not apparent from the current literature showing limited overlaps between the QM, simulation and bioinformatics studies of the nucleic acids backbone, there in fact should be a major cooperative interaction between these three approaches in studies of the sugar–phosphate backbone. The present status of the research is then illustrated by selected examples which include classification of DNA and RNA backbone families, benchmark structure–energy quantum chemical calculations, parameterization of the dihedral space of simulation force fields, incorporation of arsenate into DNA, sugar–phosphate backbone self-cleavage in small RNA enzymes, and intricate geometries of the backbone in recurrent RNA building blocks. DNA consists of a pair of strands of a sugar-phosphate backbone attached to a set of pyrimidine and purine bases (Fig. We highlight main features, advantages and limitations of these techniques, with a special emphasis given to their synergy. PNAs (peptide nucleic acids) are synthetic DNA analogues, which have a peptide, rather than a sugar-phosphate backbone.PNAs interact with high specificity with both DNA and RNA via Watson and Crick hydrogen bonds and Hoogsteen interactions. As you likely know, DNA serves as a template for transcription to produce messenger RNA (mRNA). Find Sugar Phosphate Backbone stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in the Shutterstock collection. We provide a side by side overview of structural biology/bioinformatics, quantum chemical and molecular mechanical/simulation studies of the nucleic acids backbone. The phosphate groups that make up the sugar-phosphate backbone are responsible. Knowledge of geometrical and physico-chemical properties of the sugar–phosphate backbone substantially contributes to the comprehension of the structural dynamics, function and evolution of nucleic acids.
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